Chun Chen

Scientist Amegen Inc. Thousand Oaks, CA Email: chunc@amegen.com Tel: 540-200-8818

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Previous position at VT: PhD student, 2008-11; Postdoctoral Fellow, 2014.

Research Pages: Tyson Lab

Current Research Interests

My primary interest of research focuses on applying computational techniques to study dynamics of biological systems, so as to shed light on our understandings of life behaviors, especially the underlying mechanisms behind complex diseases(such as cancer).

Presently I am working on modeling signaling trasduction pathways to explain dynamical cellular behaviors (e.g. cell proliferation and cell death) in mammalian cells. I am particularly interested in cell life/death decision mechanism in which both survival and death signaling pathways are tightly interweaved and balanced. Besides, I am also participating in a estrogen receptor signaling project. I hope to combine both experimental and computational tools to elucidate the mechanism of breast cancer placiticity and encocrine resistance, which may contribute to our understanding of better therapies on breast cancer treatment.

Education

Ph.D. 2013 Virginia Tech, Genomics, Bioinformatics and Computational Biology.
M.S. 2008 Nanjing University, China, Biochemistry and Molecular Biology.
B.S. 2005 Nanjing University, China, Biotechnology.

Professional Experience

Jan 2014 - May 2014 Postdoctoral Fellow, Dr. John Tyson's Lab, Virginia Tech, Blacksburg, VA
Sep 2008 - Dec 2013 PhD Student, Genetics Bioinformatics and Computational Biology Program, Virginia Tech
For a detailed description of Chun' professional experience, please visit his Personal Home Page .

Publications

Chen, C., Baumann, W.T., Xing, J., Xu, L., Clarke, R., and Tyson, J.J. (2014). Mathematical models of the transitions between endocrine therapy response and resistant states in breast cancer. J Roy Soc Interface 11, 20140206.
[Abstract] [Article]
Chen, C., Baumann, W.T., Clarke, R., and Tyson, J.J. (2013). Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells. FEBS Lett 587:3327-3334.
[Abstract] [Article]
Clarke, R., Shajahan, A.N., Wang, Y., Tyson, J.J., Riggins, R.B., Weiner, L.M., Baumann, W.T., Xuan, J., Zhang, B., Facey, C.,Aiyer, H., Cook, K., Hickman, F. E.,Tavassoly, I., Verdugo, A., Chen, C., Zwart, A., Warri, A., and Hilakivi-Clarke, L. A. (2011). Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Hormone Mol. Biol. Clin. Invest 5: 35-44.
[Abstract]
Tyson, J.J., Baumann, W.T., Chen, C., Verdugo, A., Tavassoly, I., Wang, Y., Weiner, L.M., and Clarke, R. (2011). Dynamic modelling of eostrogen signalling and cell fate in breast cancer cells. Nat. Rev. Cancer 11: 523-532.
[Abstract] [Article]

Personal

Chun was born in Zhenjiang, a small but beatiful city in China. He now lives in Blacksburg, VA together with his wife Lingling XU, who is also a gradute student in Virginia Tech. They like watching TV/movies and cooking in their spare time.