Tian Hong

Assistant Professor Dept. of Biochemistry & Cellular and Molecular Biology University of Tennessee 1414 Cumberland Avenue Knoxville, TN 37996-0840 Email: hongtian@utk.edu Tel: 865-974-3089 (O), 865-974-5480 (Lab)

Link to Tian Hong at Univ. Tenn
Previous position at VT: PhD student, 2009-13.

Research Pages: Tyson Lab Hong's Lab of Computational Systems Biology at Univ. Tenn

Current Research Interests

Tian is currently working on a research project that involves constructing mathematical models for T cell differentiation. T cells are unique type of cells in the sense that they have multiple stable steady states, which would correspond to different states of cell differentiation. By building the mathematical model, we will be able to understand how robust the signaling pathways are with respect to the cell-fate determination, and how the history of stimulation affects T cell differentiation.


Ph.D. 2013 Virginia Tech, Genomics, Bioinformatics and Computational Biology.
M.S. 2009 Nanyang Technological University, Singapore, Bioinformatics.
B.S. 2006 Nanyang Technological University, Singapore, Biological Sciences.


Hong, T., Oguz, C., and Tyson, J.J. (2015). A mathematical framework for understanding four-dimensional heterogeneous differentiation of CD4+ T cells. Bull. Math. Biol. 77 (6): 1046-1064.
[Abstract] [Article]
Jensen, R. V., Depasquale, S.M., Harbolick, E.A., Hong, T., Kernell, A.L., Kruchko, D. H., Modise, T., Smith, C. E., McCarter, L. L., and Stevens, A. M. (2013). Complete Genome Sequence of Prepandemic Vibrio parahaemolyticus BB22OP. Genome announcements 1, e00002-12.
[Abstract] [Article]
Hong, T., Xing, J., Li, L., and Tyson, J.J. (2012). A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells. BMC Syst. Biol. 6:66.
[Abstract] [Article]
Lin, X., Hong, T., Mu, Y., and Torres, J. (2012). Identification of residues involved in water versus glycerol selectivity in aquaporins by differntial residue pair co-evolution. Biocim. Biophys. Acta 1818:907-914.
[Abstract] [Article]
Hong, T., Xing, J., Li, L., and Tyson, J.J. (2011). A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput. Bio.l 7: e1002122.
[Abstract] [Article]


In his spare time, Tian loves playing his flute and listening to classical music. He is a karaoke fan as well.