Modeling the Budding Yeast Cell Cycle

Cdc6, as well as Sic1, is a potent inhibitor of Clb2. Therefore over-expression of either one will rescue the telophase arrest of CLB2-db∆.


Genotype Phenotype

CLB2-db∆

CLB2-db∆ GAL-SIC1

CLB2-db∆ GAL-CDC6


Arrests in telophase (Wasch & Cross, 2002).

Viable (Cross, 2003).

Viable (prediction).




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