Modeling the Budding Yeast Cell Cycle

Predictions (x):

The ability of Cdc20 over-expression to rescue the lethality of the triple-antagonist (sic1∆ cdc6∆2-49 cdh1∆) critically depends on the checkpoint mechanism.


Genotype Phenotype

sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20

quadruple mutant + mad2∆


Viable (Archambault et al., 2003).

 

Inviable, G2 arrest (prediction).




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