Modeling the Budding Yeast Cell Cycle

APC-A

Simulation:

Change of parameters: ka20"=0.
Length of G1 phase: 27.4 min.
Mass at division: 3.86.

Experiments:

Rudner, A.D. and Murray, A.W. (2000b). Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J. Cell Biol. 149:1377-1390.
[Abstract] [Article]
Cross, F.R. (2003). Two redundant oscillatory mechanisms in the yeast cell cycle. Dev. Cell 4:741-752.
[Abstract] [Article]
Experimental results: Rudner: Fig. 6, viable. Sister separation is delayed by 20 min, Clb2 degradation is delayed by more than 40 min.
Comments: In simulation, G2 is longer than WT by 9 min.