Modeling the Budding Yeast Cell Cycle

bck2∆

Simulation:

Change of parameters: B0=0
Length of G1 phase: 56.2 min.
Mass at division: 3.9.

Experiments:

Epstein, C.B. and Cross, F.R. (1994). Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START. Mol. Cell. Biol.14:2041-2047.
[Abstract] [Article]
Di Como, C.J., Chang, H. and Arndt, K.T. (1995). Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol. Cell. Biol. 15:1835-1846.
[Abstract] [Article]
Experimental results: Size is 1.3X of WT (Epstein) and 1.5X of WT (Di Como).
Comments: In simulation, size is 1.5X of WT.