Modeling the Budding Yeast Cell Cycle

cdc6∆2-49

Simulation:

Change of parameters: ksf6'=ksf6"=ksf6"'=0.
Length of G1 phase: 40.6 min.
Mass at division: 2.46.

Experiments:

Calzada, A., Sacristan, M., Sanchez, E. and Bueno, A. (2001). Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature 412:355-358.
[Abstract] [Article]
Nguyen, V.Q., Co, C. and Li, J.J. (2001). Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411:1068-1073.
[Abstract] [Article]
Experimental results: Viable. Deletion of the n-terminal 47 amino acids(#2 to #49) of Cdc6 protein, eliminates its CKI activity, but does not affect its role as a licensing factor for DNA replication.
Comments: