- Cdc6 Mutants
- cdc6∆2-49
- cdh1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49 cdh1∆
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
- swi5∆
- swi5∆ cdh1∆
- swi5∆ cdh1∆ GAL-SIC1
- swi5∆ GAL-CLB2
- CLB2-db∆ GAL-CDC6
- CLB2-db∆ multicopy CDC6
- APC-A cdh1∆ GAL-CDC6
- APC-A cdh1∆ multicopy CDC6
- APC-A sic1∆ cdc6∆2-49
cdc6∆2-49
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksf6'=ksf6"=ksf6"'=0.
Length of G1 phase: 40.6 min.
Mass at division: 2.46.
Experiments:
Calzada, A., Sacristan, M., Sanchez, E. and Bueno, A. (2001). Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature 412:355-358.
[Abstract] [Article]
[Abstract] [Article]
Nguyen, V.Q., Co, C. and Li, J.J. (2001). Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411:1068-1073.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Viable. Deletion of the n-terminal 47 amino acids(#2 to #49) of Cdc6 protein, eliminates its CKI activity, but does not affect its role as a licensing factor for DNA replication.
Comments:
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