Modeling the Budding Yeast Cell Cycle

cdc14-ts

Simulation:

Change of parameters: ks14=0.
Length of G1 phase: 32.4 min.
Arrest: Telophase arrest.

Experiments:

Fitzpatrick, P.J., Toyn, J.H., Millar, J.B. and Johnston, L.H. (1998). DNA replication is completed in Saccharomyces cerevisiae cells that lack functional Cdc14, a dual-specificity protein phosphatase. Mol. Gen. Genet. 258:437-441.
[Abstract] [Article]
Visintin, R., Craig, K., Hwang, E.S., Prinz, S., Tyers, M. and Amon, A. (1998). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2:709-718.
[Abstract] [Article]
Experimental results: Telophase arrest.
Comments: