Modeling the Budding Yeast Cell Cycle

tem1∆

Simulation:

Change of parameters: ka15"=0.002 (=ka15').
Length of G1 phase: 33.6 min.
Arrest: Telophase arrest.

Experiments:

Shirayama, M., Matsui, Y. and Toh-e, A. (1994b). The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol. Cell. Biol. 14:7476-7482.
[Abstract] [Article]
Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998). A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9:2803-2817.
[Abstract] [Article]
Experimental results: Telophase arrest.
Comments: