Modeling the Budding Yeast Cell Cycle

sic1∆

Simulation:

Change of parameters: ksc1'=ksc1"=0.
Length of G1 phase: 9.7 min.
Mass at division: 2.32.

Experiments:

Schneider, B.L., Yang, Q.-H. and Futcher, A.B. (1996). Linkage of replication to Start by the Cdk inhibitor Sic1. Science 272:560-562.
[Abstract] [Article]
Experimental results: Fig. 4, the mutant is viable, it replicates DNA much earlier than the wild-type cells, but buds at about the same time.
Comments: In simulation, sic1∆ has a G1 length of 9.7 min (wiild type, 35.7 min), budding occurs at 28.8 min (wild type, 32.7 min), and is 90% wild type size.