- Sic1 Mutants
- sic1∆
- sic1∆ cdh1∆
- sic1∆ cdh1∆ GALL-CDC20
- sic1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49 cdh1∆
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
- GAL-CLB2 sic1∆
- GAL-CLB5 sic1∆
- CLB5-db∆ sic1∆
- APC-A sic1∆
- APC-A sic1∆ cdc6∆2-49
- cdc14-ts sic1∆
- cln1∆ cln2∆ sic1∆
- cln3∆ bck2∆ sic1∆
- cln1∆ cln2∆ cln3∆ sic1∆
- swi5∆
- swi5∆ GAL-CLB2
- swi5∆ cdh1∆
- swi5∆ cdh1∆ GAL-SIC1
- GAL-SIC1
- GAL-SIC1-db∆
- GAL-SIC1 cln1∆ cln2∆
- GAL-SIC1 GAL-CLN2 cln1∆ cln2∆
- GAL-SIC1 cln1∆ cln2∆ cdh1∆
- GAL-SIC1 GAL-CLN2 cln1∆ cln2∆ cdh1∆
- CLB2-db∆ multicopy SIC1
- CLB2-db∆ GAL-SIC1
- cdc14-ts GAL-SIC1
- cdc14ts then GAL-SIC1
- APC-A cdh1∆ GAL-SIC1
- APC-A cdh1∆ multi-copy SIC1
sic1∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksc1'=ksc1"=0.
Length of G1 phase: 9.7 min.
Mass at division: 2.32.
Experiments:
Schneider, B.L., Yang, Q.-H. and Futcher, A.B. (1996). Linkage of replication to Start by the Cdk inhibitor Sic1. Science 272:560-562.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 4, the mutant is viable, it replicates DNA much earlier than the wild-type cells, but buds at about the same time.
Comments: In simulation, sic1∆ has a G1 length of 9.7 min (wiild type, 35.7 min), budding occurs at 28.8 min (wild type, 32.7 min), and is 90% wild type size.
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