Modeling the Budding Yeast Cell Cycle

APC-A cdh1∆ multi-copy SIC1

Simulation:

Change of parameters: ka20"=0, ksc1'=0.036, ksc1"=0.36 (=3 copies), kscdh=0, init CDH1T=CDH1=0.

Experiments:

Cross, F.R. (2003). Two redundant oscillatory mechanisms in the yeast cell cycle. Dev. Cell 4:741-752.
[Abstract] [Article]
Experimental results: Table1, rescued.
Comments: In our simulation, mass keeps increasing after each cycle and the cell eventually arrests after 14 cycles.