Modeling the Budding Yeast Cell Cycle

GAL-SIC1

Simulation:

Change of parameters: ksc1'=0.12, MDT=150.
Length of G1 phase: 144.8 min.
Mass at division: 2.81.

Experiments:

Nugroho, T.T. and Mendenhall, M.D. (1994). An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol. Cell. Biol. 14:3320-3328.
[Abstract] [Article]
Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G. and Deshaies, R.J. (1997a). Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278:455-460.
[Abstract] [Article]
Experimental results: Verma, Fig. 3B, viable. Nugroho, Fig. 2, most cells are viable but large.
Comments: Size 1.1X WT.