Modeling the Budding Yeast Cell Cycle

cdc14-ts GAL-SIC1

Simulation:

Change of parameters: ks14=0, ksc1'=0.12, MDT=150.
Length of G1 phase: 121.5 min.
Arrest: Telophase arrest.

Experiments:

Fitzpatrick, P.J., Toyn, J.H., Millar, J.B. and Johnston, L.H. (1998). DNA replication is completed in Saccharomyces cerevisiae cells that lack functional Cdc14, a dual-specificity protein phosphatase. Mol. Gen. Genet. 258:437-441.
[Abstract] [Article]
Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998). A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9:2803-2817.
[Abstract] [Article]
Yuste-Rojas, M. and Cross, F.R. (2000). Mutations in CDC14 result in high sensitivity to cyclin gene dosage in Saccharomyces cerevisiae. Mol. Gen. Genet. 263:60-72.
[Abstract] [Article]
Experimental results: Jaspersen, Table 4, weakly rescued. Fitzpatrick, Fig. 2. Yuste-Rojas, Fig. 3D, weakly rescued.
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