Modeling the Budding Yeast Cell Cycle

cdc14-ts sic1∆

Simulation:

Change of parameters: ksc1'=ksc1"=0, 16% Cdc14 activity (kppc1=kppf6=0.64, kaswi=0.32, kacdh"=0.128).
Arrest: Synthetically lethal, telophase arrest when Cdc14 activity is reduced.

Experiments:

Yuste-Rojas, M. and Cross, F.R. (2000). Mutations in CDC14 result in high sensitivity to cyclin gene dosage in Saccharomyces cerevisiae. Mol. Gen. Genet. 263:60-72.
[Abstract] [Article]
Experimental results: Fig. 3, synthetically lethal at 29C (a permissive temperature of cdc14-ts).
Comments: