Modeling the Budding Yeast Cell Cycle

cln1∆ cln2∆ cln3∆ GAL-CLN3

Simulation:

Change of parameters: ksn2'=ksn2"=0, Dn3=20, MDT=150.
Length of G1 phase: 43.6 min.
Mass at division: 1.4.

Experiments:

Cross, F.R. (1990) Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-1 arrest and is independent of the mating-pheromone signalling pathway. Mol. Cell. Biol. 10: 6482-6490.
[Abstract] [Article]
Schwob, E. and Nasmyth, K.(1993). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7:1160-1175.
[Abstract] [Article]
Experimental results: Viable. Schwob: Fig. 2, SBF activated soon after galactose induction.
Comments: