Modeling the Budding Yeast Cell Cycle

cln1∆ cln2∆ cln3∆ apc-ts

Simulation:

Change of parameters: ksn2'=ksn2"=0, Dn3=0, ks20=ks20"=0, kscdh=0, init CDH1T=CDH1=0.
Length of G1 phase: 190.6 min.
Arrest: Metaphase arrest.

Experiments:

Irniger, S. and Nasmyth, K. (1997). The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. J. Cell Sci. 110:1523-1531.
[Abstract] [Article]
Experimental results: Fig. 2, metaphase arrest.
Comments: