Modeling the Budding Yeast Cell Cycle

cln1∆ cln2∆ cln3∆ multicopy BCK2

Simulation:

Change of parameters: ksn2'=ksn2"=0, Dn3=0, B0=0.324 (=6 copies).
Length of G1 phase: 49.8 min.
Mass at division: 8.75.

Experiments:

Epstein, C.B. and Cross, F.R. (1994). Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START. Mol. Cell. Biol.14:2041-2047.
[Abstract] [Article]
Experimental results: Viable, a low copy number (CEN) plasmid carrying the BCK2 gene can suppress the lethality of triple-cln deletion.
Comments: