Modeling the Budding Yeast Cell Cycle

cln1∆ cln2∆ sic1∆

Simulation:

Change of parameters: ksn2"=0, ksc1'=ksc1"=0.
Length of G1 phase: 6.4 min
Mass at division: 3.59

Experiments:

Dirick, L., Bohm, T. and Nasmyth, K. (1995). Roles and regulation of Cln/Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14:4803-4813.
[Abstract] [Article]
Experimental results: Fig 4, size between cln1∆ cln2∆ and WT.
Comments: Mass at division for cln1∆ cln2∆= 6.39 and for WT= 2.62.