Modeling the Budding Yeast Cell Cycle

cln3∆ bck2∆ sic1∆

Simulation:

Change of parameters: B0=0, Dn3=0, ksc1'=ksc1"=0.
Length of G1 phase: 123.6 min.

Experiments:

Wijnen, H., and Futcher, B. (1999) Genetic analysis of the shared role of CLN3 and BCK2 at the G1-S transition in Saccharomyces cerevisiae. Genetics 153:1131-1143.
[Abstract] [Article]
Experimental results: Fig. 5, not rescued.
Comments: In our simulation, in the first cycle, this strain cannot bud until mass=9.3, and it divides at mass 13.5 (after 10, the cell is considered inviable). Moreover, the mass gets even bigger in the second cycle, then it arrests. We conclude that the mutant is inviable.