Modeling the Budding Yeast Cell Cycle

sic1∆ cdc6∆2-49

Simulation:

Change of parameters: ksc1'=ksc1"=0, ksf6'=ksf6"=ksf6"'=0.
Length of G1 phase: 13.4 min.
Mass at division: 2.18.

Experiments:

Calzada, A., Sacristan, M., Sanchez, E. and Bueno, A. (2001). Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature 412:355-358.
[Abstract] [Article]
Wasch, R. and Cross, F. (2002). APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418:556-562.
[Abstract] [Article]
Experimental results: Viable. Although this double mutant was first reported by Calzada et al. (Fig. 4) as inviable and arrested in telophase, but the result was challenged by Wasch and Cross who found that it is viable. Viability was later confirmed by A. Bueno (personal communication).
Comments: