Modeling the Budding Yeast Cell Cycle

swi5∆ cdh1∆


Change of parameters: ksswi'= ksswi"=0, kscdh=0, init CDH1=CDH1T=0.
Arrest: Inviable, telophase arrest.


Archambault, V., Li, C.X., Tackett, A.J., Wasch, R., Chait, B.T., Rout, M.P. and Cross, F.R. (2003). Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit. Mol. Biol. Cell 14:4592-4604.
[Abstract] [Article]
Experimental results: Similar to the triple-antagonist. They were able to undergo DNA synthesis and nuclear division, but not cell division and arrested as binucleate cells with 4C DNA content.
Comments: Problem for the model. The double mutant swi5∆ cdh1∆ has similar phenotype to the triple-antagonist, because with Swi5 deletion, Sic1 and Cdc6 synthesis are drastically reduced. And our model is at odds with this mutant as well.