Modeling the Budding Yeast Cell Cycle

• Home
• Introduction
• Rationale
• Budding yeast biology
• Components & function
• Cell cycle progression
• Basic mechanism
• Major improvement
• Overview
• Wiring diagram
• Description
• Justification
• Cyclins
• Cdc20
• Cdh1
• Cdc14 activation
• Mitotic Exit Network
• Pds1/Esp1 interaction
• CKI
• Checkpoint proteins
• Formulation
• Simulation
• Conclusions
• Mathematical Model
• Equations
• Parameters
• Problems
• Predictions
• Robustness
• Mutants
• List of Mutants
• WT in glucose
• WT in galactose
• Cln
• Bck2
• cln1 cln2 cln3
• Clb5 Clb6
• Clb1 Clb2
• Sic1
• Cdc6
• Cdh1
• Cdc20
• APC
• MEN pathway
• Exit-of-mitosis
• Pds1 / Esp1
• Checkpoint
• PPX
• Model Downloads
• Previous model
• Current model
• Target model
• APC-del model
• Modeling Tools
• Get WinPP
• How to use WinPP
• JigCell
• Oscill8
• PET
• Simulate the Model
• Other Models
• The "target" model
• "APC-del" model
• Generic model
• Literature
• References
• Publications
• Who We Are
• Va Tech
• BUTE
• Rockefeller Univ.

(Sept. 2003, left-to-right) Bolan Ling-Hu, Bela Novak, Dorjsuren Battogtokh, Amit Dravid, John Tyson, Mohsen Sabouri, Emery Conrad, Kathy Chen, Marc Vass, Laurence Calzone, Andrea Ciliberto, Chris Hong, Jason Zwolak
(not pictured: Nick Allen, Bob Ball, Tom Panning, Ranjit Randhawa)

Tyson's Lab:

• John J. Tyson: University Distinguished Professor, Dept. of Biology, Virginia Tech, Blacksburg, VA, USA.
• Kathy Chen: Research Scientist.
• Laurence Calzone: Ph.D. (Dec. 2003).
• Jason Zwolak: Ph.D. (Computer Science, Dec. 2004).

More pictures of people in Tyson's Lab