Modeling the Budding Yeast Cell Cycle

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• Introduction
• Rationale
• Budding yeast biology
• Components & function
• Cell cycle progression
• Basic mechanism
• Major improvement
• Overview
• Wiring diagram
• Description
• Justification
• Cyclins
• Cdc20
• Cdh1
• Cdc14 activation
• Mitotic Exit Network
• Pds1/Esp1 interaction
• CKI
• Checkpoint proteins
• Formulation
• Simulation
• Conclusions
• Mathematical Model
• Equations
• Parameters
• Problems
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• Robustness
• Mutants
• List of Mutants
• WT in glucose
• WT in galactose
• Cln
• Bck2
• cln1 cln2 cln3
• Clb5 Clb6
• Clb1 Clb2
• Sic1
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WILD TYPE in galactose

Simulation

Daughter cell	Mother cell
In galactose, MDT=150 min.
Length of G1 phase: 108.4 min.	Length of G1 phase: 40.4 min.
Unbudded period: 110.3 min.	Unbudded period: 38.3 min.
Cycle time: 189.9 min.	Cycle time: 116.1 min.
Mass at division: 1.92.	Mass at division: 2.01.

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