Wiring diagram of the generic cell cycle regulatory network.
Here we show all the major regulatory interactions that have been proposed for different eukaryotic organisms. Solid lines - reactions, dashed lines - regulatory interactions, a protein sitting on a reaction arrow represents activation. Regulatory modules of the system are distinguished by colored backgrounds: 1 - exit of M module, 2 - Cdh1 module, 3 - CycB transcription factor, 4 - CycB synthesis/degradation, 5 - G2 module, 6 - CycB inhibiton by CKI (also introduces the binding of phosphorylated CycB, if that is present), 7 - CKI transcription factor, 8 - CKI synthesis/degradation, 9 - CycE inhibition by CKI, 10 - CycE synthesis/degradation, 11 - CycE/A transcription factor, 12 - CycA inhibition by CKI, 13 - CycA synthesis/degradation. In the name conversion table we collected the protein names of each regulator in the investigated organisms that correspond to the names used here. Open mouthed Pac-Man represents active form of regulated protein; grey rectangles behind cyclins represent their not modeled, fast binding to corresponding Cdk's. In the equations we represent preMPF = CycB-P + CKI/CycB-P signs of this figure and TriB = CKI/CycB + CKI/CycB-P.
This table tells which module was used in our simulations of different organisms.