Generic Cell Cycle Model

Conclusion

We proposed a cell cycle model that holds most general principles of the known key interactions that has been reported for eukaryotic organisms from yeasts to mammals.
With this approach we got a wiring diagram and a set of equations that can simulate the basic cell cycle behaviors of these organisms, depending on which parameter set we feed into the model.
We also validated the model by checking the behaviors of mutants of budding yeast, fission yeast and mammalian cells.
The full model consists of 13 modules: four synthesis - degradation modules (4, 8, 10, 13), three stoichometric binding and inhibition modules (6, 9, 12), three transcription factor modules (3, 7, 11), and three modules with multiple activation - inhibition steps (1, 2, 5).
One dimensional bifurcation diagrams show how cell physiology (cell mass) determines transitions (bifurcations) between cell cycle phases (attractors of the system).
Two dimensional bifurcation diagrams show what kind of transitions a mutation can cause to the dynamics of the regulatory system.
We predicted the growth rate dependent viability of budding yeast cells perturbed in the mitotic exit module.
We proposed two possible oscillations (endoreplication and normal mitotic cycles) for intermediate Cdc13 activities in fission yeast cells.
For downloading model equations and parameters, go to Help to recreate our results page.