Rajat Singhania

Bioinformatics Programmer LifeLabsGenetics.com 175 Galaxy Blvd., Toronto, ON Canada M9W 0C9 Email: rajat.singhania@lifelabs.com
rajitz@gmail.com Tel: 647-631-4325

Link to LifeLabsGenetics.com
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Previous positions at VT: PhD student, 2005-11; Project Assoc., May-Dec 2011.

Research Pages: Tyson Lab

Current Research Interests

My first research project in the lab involved building a so-called "hybrid model" of mammalian cell cycle control. Purely discrete (Boolean-based) models that represent the activation or inactivation of proteins in regulatory networks are too crude, whereas purely continuous (ODEs-based) are both hard to parameterize and relatively difficult to build. The hybrid model, which uses ODEs for cyclins that contain Boolean variables to represent cyclin regulators, has been able to successfully simulate flow cytometry data from colon carcinoma cells. This work shall be submitted for publication very soon!!

These days I am working on another project which involves finding 3-node regulatory motifs that display a certain characteristic behavior, such as signal adaptation. This work shall be submitted for publication a few months before my expected graduation in May 2010.

Education

Ph.D. 2011 Virginia Tech, Genomics, Bioinformatics and Computational Biology.
B.S. 2005 Virginia Tech, Computer Science.

Professional Experience

Jan-Nov 2012 Research Fellow, Cincinnati Children's Hospital, Medical Center, OH.
Summer 2007 Internship at Merrimack Pharmaceuticals, Cambridge, MA.

Conference Proceedings

Singhania, R., Jacobberger, J.W., and Tyson J.J. (2009). A Hybrid Model of the Mammalian Cell Cycle. Computational Cell Biology Meeting at Cold Spring Harbor Laboratories. March 24-27, 2009. Cold Spring Harbor, N.Y.
Singhania, R., Jacobberger, J.W., and Tyson J.J. (2008). A Hybrid Model of the Mammalian Cell Cycle. Frontiers of Applied and Computational Mathematics. May 19-21, 2008. Newark, N.J.

Publications