- Cdc20 Mutants
- cdc20-ts
- cdc20∆ clb5∆
- cdc20∆ pds1∆
- cdc20∆ pds1∆ clb5∆
- CLB5-db∆ pds1∆ cdc20∆
- cdc20-ts bub2∆
- cdc20-ts mad2∆
- net1∆ cdc20-ts
- GAL-ESP1 cdc20-ts
- GAL-CDC20
- APC-A cdh1∆ multicopy CDC20
- sic1∆ cdh1∆ GALL-CDC20
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
CLB5-db∆ pds1∆ cdc20∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: kdb5"=0, ks1pds"=ks2pds"=0,
ks20'=ks20"=0.
Length of G1 phase: 34.5 min.
Arrest: Telophase arrest.
Experiments:
Wasch, R. and Cross, F. (2002). APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418:556-562.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 1, telophase arrest.
Comments: This shows that Cdc20 has other essential targets beside Clb5 and Pds1, namely Clb2.
webmaster