- Cdc20 Mutants
- cdc20-ts
- cdc20∆ clb5∆
- cdc20∆ pds1∆
- cdc20∆ pds1∆ clb5∆
- CLB5-db∆ pds1∆ cdc20∆
- cdc20-ts bub2∆
- cdc20-ts mad2∆
- net1∆ cdc20-ts
- GAL-ESP1 cdc20-ts
- GAL-CDC20
- APC-A cdh1∆ multicopy CDC20
- sic1∆ cdh1∆ GALL-CDC20
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
GAL-CDC20
debug: ,
test user =
test db =
Simulation:
Change of parameters: ks20'=6, MDT=150.
Length of G1 phase: 269.4 min.
Arrest: Mitotic catastrophe.
Experiments:
Shirayama, M., Zachariae, W., Ciosk, R. and Nasmyth, K. (1998). The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17:1336-1349.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 7, inviable, mitotic catastrophe.
Comments: The mutant is diagonsed as inviable and died of mitotic catastrophe, because Esp1 is high before [SPN] reaches 1.
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