Caulobacter Cell Cycle Control

Genetic network of cell cycle control in Caulobacter

Figure 3. Known cell cycle genes in Caulobacter crescentus (adapted from (McAdams and Shapiro, 2003)). Regulation of genes by CtrA is shown in red, by GcrA in blue, by DnaA in green, and by CcrM in cyan. The cyan stars indicate those genes whose transcription is regulated by DNA methylation The CtrA-driven upregulation of the dnaA gene (red line with ? mark) is suggested by microarray data (Laub et al., 2002; McAdams, 2005). DnaA self-regulation (blue line with ? mark) is proposed from the fact that the dnaA promoter has DnaA boxes (Zweiger and Shapiro, 1994).