Modeling the Budding Yeast Cell Cycle


The model lumps together redundant cyclins: "Cln2" stands for Cln1 and Cln2, "Clb2" for Clb1 and Clb2, and "Clb5" for Clb5 and Clb6, respectively.

Cdc28/Cln3 (with the help of Bck2) initiates Start, when cell size reaches a critical value, by activating the transcription factors SBF and MBF (for Cln2 and Clb5 respectively).

Cdc28/Cln2 induces budding.

Cdc28/Clb5 is responsible for proper timing of DNA replication.

Cdc28/Clb2 is essential for entry into mitosis.