Modeling the Budding Yeast Cell Cycle

Pds1 and Esp1

Esp1 is essential for dissolving the cohesins that hold the sister chromatids together. Esp1 activation results in proper separation of sister chromatids at anaphase (Review, Yanagida, 2000; Nasmyth et al., 2000). Pds1 binds to Esp1 and inhibits its activity (Ciosk et al., 1998).


Pds1 (securin)
Esp1 (separase)

Level and regulation::