Modeling the Budding Yeast Cell Cycle



The molecular machinery of eukaryotic cell cycle control is known in more detail for budding yeast, Saccharomyces cerevisiae, than for any other organism. Molecular biologists have painstakingly dissected and characterized individual components and their interactions to derive a consensus picture of the regulatory network (wiring diagram).

Can this model explain the physiology of the intact cell? What genetic experiments can it account for? The only way to address these questions is to formulate the picture as a mathematical model, and study it thoroughly and rigorously. Where there is correspondence between the model and experiment, we can have some confidence that our understanding of the control mechanism is adequate. Where the model fails will point to aspects that need further study.

This is a companion website for the paper:
Chen, K.C., Calzone, L., Csikasz-Nagy, A., Cross, F.R., Novak, B., and Tyson, J.J. (2004). Integrative analysis of cell cycle control in budding yeast. Mol. Biol. Cell 15:3841-3862