Predictions (ii):
cln3∆ bck2∆ is inviable. So are the triple mutants cln3∆ bck2∆ sic1∆ and cln3∆ bck2∆ cdc6∆2-49.
| Genotype | Phenotype |
|
cln3∆ bck2∆ cln3∆ bck2∆ sic1∆ cln3∆ bck2∆ cdc6∆2-49 |
Inviable, G1 arrest (Epstein & Cross, 1994) Inviable (Wijnen & Futcher, 1999). Inviable (prediction) |
In all three mutants, SBF never activates, Cln2 is not synthesized. Neither SIC1 deletion nor CDC6∆2-49 can rescue the inviability of cln3∆ bck2∆.
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