Equations
A description of how the equations are formulated is presented in Chen et al., 2004.Equation for growth
Equations governing cyclin-dependent kinases:
Equations governing the inhibitors of Clb-dependent kinases:
Equations governing Clb degradation machinery:
Equations for the MEN pathway:
Equations governing the phosphatases:
Equations for Pds1, Esp1 and their interaction:
Equations for DNA synthesis, budding and spindle formation:
Goldbeter Function:
Equations governing the transcription factors:
Reset Rules:
When [Clb2] drops below 
as cell exits mitosis, we reset [BUD] and [SPN] to zero, and divide the mass between daughter and mother cells as follows: 
for daughter, and 
for mother, with 
, where
D is the daughter cycle time. Lord & Wheals, 1980 found empirically that D and growth rate 
are related by the equation, 
. For a culture growing at a mass-doubling-time of 90 min,
. When 
drops below 
, [ORI] is reset to 0.
Flags:
Bud emergence when
, start DNA synthesis when 
, chromosome alignment on spindle completed when
.
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