## Equations

A description of how the equations are formulated is presented in Chen et al., 2004.Equation for growth

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}

Equations governing cyclin-dependent kinases:

_{
}

Equations governing the inhibitors of Clb-dependent kinases:

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_{}

Equations governing Clb degradation machinery:

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Equations for the MEN pathway:

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Equations governing the phosphatases:

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Equations for Pds1, Esp1 and their interaction:

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Equations for DNA synthesis, budding and spindle formation:

_{}

Goldbeter Function:

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Equations governing the transcription factors:

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_{}

_{}

_{}

**Reset Rules: **

When [Clb2] drops below _{} as cell exits mitosis, we reset [BUD] and [SPN] to zero, and divide the mass between daughter and mother cells as follows: _{}
for daughter, and _{} for mother, with _{}, where
*D* is the daughter cycle time. Lord & Wheals, 1980 found empirically that *D* and growth rate _{} are related by the equation, _{
}. For a culture growing at a mass-doubling-time of 90 min,
_{}. When _{} drops below _{}, [ORI] is reset to 0.

**Flags:**
Bud emergence when_{,} start DNA synthesis when _{,} chromosome alignment on spindle completed when
_{.}