Modeling the Budding Yeast Cell Cycle

Predictions (iii):

The mutant GAL-CLB5 is alive ( Schwob & Nasmyth, 1993), which depends on the inhibition of Sic1 on Clb5 activity for viability. Since Cdc6 is not an efficient inhibitor of Clb5, deletion will not affect the viability of GAL-CLB5.

Genotype Phenotype

GAL-CLB5 sic1∆


GAL-CLB5 cdc6∆2-49

Inviable, inefficient origin licensing
(Jacobson et al., 2000).

Viable, size similar to WT (prediction).

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