Modeling the Budding Yeast Cell Cycle

Predictions (xii):

Mutant cln1∆ cln2∆ clb5∆ clb6∆ can not make bud, it cannot be rescued by over-expression of Clb2.

Genotype Phenotype

cln1∆ cln2∆ clb5∆ clb6∆


quadruple mutant + GAL-CLB2
(or + cdh1∆)

Inviable, arrests in G1 (Schwob & Nasmyth, 1993).

Able to do DNA synthesis and mitosis, but no bud formation. Becoming dinucleate, similar to cdc24-ts (prediction).

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