Modeling the Budding Yeast Cell Cycle

cdc20-ts

Simulation:

Change of parameters: ks20'=ks20"=0.
Length of G1 phase: 35.1 min.
Arrest: Metaphase arrest.

Experiments:

Sethi, N., Monteagudo, M.C., Koshland, D., Hogan, E. and Burke, D.J. (1991). The CDC20 gene product of Saccharomyces cerevisiae, a beta-transducin homolog, is required for a subset of microtubule-dependent cellular processes. Mol. Cell. Biol. 11:5592-5602.
[Abstract] [Article]
Lim, H.H., Goh, P.-Y. and Surana, U. (1998). Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr. Biol. 8:231-234.
[Abstract] [Article]
Shirayama, M., Zachariae, W., Ciosk, R. and Nasmyth, K. (1998). The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17:1336-1349.
[Abstract] [Article]
Experimental results: Shirayama Fig. 6A, metaphase arrest.
Comments: