Modeling the Budding Yeast Cell Cycle
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Introduction
Rationale
Budding yeast biology
Components & function
Cell cycle progression
Basic mechanism
Major improvement
Overview
Wiring diagram
Description
Justification
Cyclins
Cdc20
Cdh1
Cdc14 activation
Mitotic Exit Network
Pds1/Esp1 interaction
CKI
Checkpoint proteins
Formulation
Simulation
Conclusions
Mathematical Model
Equations
Parameters
Problems
Predictions
Robustness
Mutants
List of Mutants
WT in glucose
WT in galactose
Cln
Bck2
cln1 cln2 cln3
Clb5 Clb6
Clb1 Clb2
Sic1
Cdc6
Cdh1
Cdc20
APC
MEN pathway
Exit-of-mitosis
Pds1 / Esp1
Checkpoint
PPX
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APC-del model
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Rockefeller Univ.
cln1%20cln2%20cln3 Mutants
debug: ,
test user =
test db =
Simulation:
Change of parameters:
Experiments: